Anaphylaxis: Anaphylaxis is reported with codeine, among the substances in promethazine HCl and codeine phosphate oral solution.

g., amiodarone, quinidine) may perhaps end in a rise in codeine plasma concentrations and also a lessen in Energetic metabolite morphine plasma focus which could bring about an analgesic efficacy reduction or signs of opioid withdrawal.

Thanks to very similar pharmacologic Attributes, it really is sensible to hope similar risk with concomitant utilization of opioid cough drugs and benzodiazepines, other CNS depressants, or Alcoholic beverages.

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Keep away from the use of promethazine HCl and codeine phosphate oral Resolution in clients who're using a CYP3A4 inhibitor, CYP3A4 inducer, or 2D6 inhibitor [see Warnings and

Effects around the Cardiovascular Program Codeine creates peripheral vasodilation which can result in orthostatic hypotension or syncope. Manifestations of histamine launch and/or peripheral vasodilation may incorporate pruritus, flushing, crimson eyes and sweating and/or orthostatic hypotension.

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Endocrine/Metabolic: Cases of serotonin syndrome, a potentially everyday living-threatening affliction, are actually documented all through concomitant utilization of opioids with serotonergic medication.

As a consequence of inconsistencies between the drug labels on DailyMed as well as the pill pictures supplied by RxImage, we now not Exhibit the RxImage tablet photographs connected to drug labels.

Propulsive peristaltic waves from the colon are lessened, although tone may very well be elevated to the point of spasm resulting in constipation. Other opioid-induced consequences may contain a discount in biliary and pancreatic secretions, spasm of sphincter of Oddi, and transient elevations in serum amylase.

This will transpire Even though you take Promethazine Hydrochloride and Codeine Phosphate Oral Answer just as prescribed by your healthcare company. Your chance of addiction, abuse, and misuse is increased if you or perhaps a relative provides a historical past of drug or Alcoholic beverages abuse or addiction, or psychological health problems.

Human Knowledge Released facts from scenario-Management and observational scientific tests on codeine use during pregnancy are inconsistent of their results. Some reports of codeine exposure showed an elevated possibility of All round congenital malformations while others did not. An increased possibility of precise malformations with codeine exposure such as respiratory malformations, spina bifida and congenital coronary heart defects had been claimed in certain studies.

Stay away legal lean for sale from the usage of promethazine HCl and codeine phosphate oral Option in adolescents 12 to 18 yrs of age who produce other possibility things that may improve their sensitivity for the respiratory depressant results of codeine Except if the benefits outweigh the dangers.

If adrenal insufficiency is diagnosed, handle with physiologic alternative doses of corticosteroids. Wean the patient off from the opioid to allow adrenal perform to Recuperate and keep on corticosteroid procedure until adrenal perform recovers. Other opioids could possibly be tried out as some scenarios reported usage of another opioid without the need of recurrence of adrenal insufficiency. The knowledge obtainable won't establish any unique opioids as staying far more prone to be related to adrenal insufficiency.